The INSIG2 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to INSIG2. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The INSIG2 antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR